Citric Acid → 5-Formylthiophene-2-Carbonitrile

HRID 307174

Reaction equation

HRID 307174 reaction equation
[CH2:38]1[O:39][CH2:40][CH2:41][CH2:42]1.[CH2:8]([Li:9])[CH2:10][CH2:11][CH3:12].[CH3:20][N:21]([CH:22]=[O:23])[CH3:24].[CH:1]([NH:2][CH:3]([CH3:4])[CH3:5])([CH3:6])[CH3:7].[OH2:43].[OH:25][C:26]([CH2:27][C:28]([C:29](=[O:30])[OH:31])([CH2:32][C:33](=[O:34])[OH:35])[OH:36])=[O:37].[s:13]1[c:14]([C:18]#[N:19])[cH:15][cH:16][cH:17]1>>[s:13]1[c:14]([C:18]#[N:19])[cH:15][cH:16][c:17]1[CH:22]=[O:23]

Participants

8

Reactant 7

HCID 311Citric AcidHCID 962WaterHCID 6228DimethylformamideHCID 7912DiisopropylamineHCID 8028TetrahydrofuranHCID 660872-ThiophenecarbonitrileHCID 178418339Butyllithium

Product 1

HCID 122800045-Formylthiophene-2-Carbonitrile

Sources & evidence

ORD record
ord-1ba29b244fd44cebb845a2acb15c98b6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Linked notes

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