Tetrahydrofuran → Ethyl 3-(1-methyl-1H-imidazol-5-yl)-3-(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)acrylate

HRID 308845

Reaction equation

HRID 308845 reaction equation
[CH2:42]1[O:43][CH2:44][CH2:45][CH2:46]1.[CH3:11][Si:12]([CH3:13])([CH3:14])[CH2:15][C:16](=[O:17])[O:18][CH2:19][CH3:20].[CH3:1][Si:2]([N-:3][Si:4]([CH3:5])([CH3:6])[CH3:7])([CH3:8])[CH3:9].[CH3:21][n:22]1[cH:23][n:24][cH:25][c:26]1[C:27](=[O:28])[c:29]1[cH:30][cH:31][c:32]([O:35][CH:36]2[O:37][CH2:38][CH2:39][CH2:40][CH2:41]2)[cH:33][cH:34]1.[Li+:10]>>[CH:15]([C:16](=[O:17])[O:18][CH2:19][CH3:20])=[C:27]([c:26]1[n:22]([CH3:21])[cH:23][n:24][cH:25]1)[c:29]1[cH:30][cH:31][c:32]([O:35][CH:36]2[O:37][CH2:38][CH2:39][CH2:40][CH2:41]2)[cH:33][cH:34]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 77687Ethyl trimethylsilylacetateHCID 3280088Npc316347HCID 57835849(1-Methyl-1H-imidazol-5-yl)(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)methanone

Product 1

HCID 68686278Ethyl 3-(1-methyl-1H-imidazol-5-yl)-3-(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)acrylate

Sources & evidence

ORD record
ord-d17f324d88994d4d9fedd2e3305502e1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Linked notes

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