Isopropanol → tert-Butyl 8-(2-(trifluoromethyl)pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-2-carboxylate

HRID 309500

Reaction equation

HRID 309500 reaction equation
[CH2:12]1[N:13]([C:22](=[O:23])[O:24][C:25]([CH3:26])([CH3:27])[CH3:28])[CH2:14][CH2:15][C:16]12[CH2:17][CH2:18][NH:19][CH2:20][CH2:21]2.[CH:29]([N:30]([CH2:31][CH3:32])[CH:33]([CH3:34])[CH3:35])([CH3:36])[CH3:37].[CH:38]([OH:39])([CH3:40])[CH3:41].[Cl:1][c:2]1[n:3][c:4]([C:8]([F:9])([F:10])[F:11])[n:5][cH:6][cH:7]1>>[c:2]1([N:19]2[CH2:18][CH2:17][C:16]3([CH2:12][N:13]([C:22](=[O:23])[O:24][C:25]([CH3:26])([CH3:27])[CH3:28])[CH2:14][CH2:15]3)[CH2:21][CH2:20]2)[n:3][c:4]([C:8]([F:9])([F:10])[F:11])[n:5][cH:6][cH:7]1

Participants

5

Reactant 4

HCID 3776IsopropanolHCID 81531DiisopropylethylamineHCID 152943694-Chloro-2-(trifluoromethyl)pyrimidineHCID 34178604tert-Butyl 2,8-diazaspiro[4.5]decane-2-carboxylate

Product 1

HCID 66701106tert-Butyl 8-(2-(trifluoromethyl)pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-2-carboxylate

Sources & evidence

ORD record
ord-5787c5f4ad7447d49e2281e71f8df9c8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Linked notes

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