1,2-Dichloroethane → Ethyl 6-chloro-2-(ethoxycarbonyl)-1-methyl-oxo-1h-indole-3-acetate

Reaction equation

[Cl-:29].[Cl-:30].[Cl-:31].[Cl-:32].[Cl:1][C:2]([C:3](=[O:4])[O:5][CH2:6][CH3:7])=[O:8].[Cl:25][CH2:26][CH2:27][Cl:28].[Cl:9][c:10]1[cH:11][cH:12][c:13]2[cH:14][c:15]([C:20](=[O:21])[O:22][CH2:23][CH3:24])[n:16]([CH3:19])[c:17]2[cH:18]1.[Ti+4:33]>>[C:2]([C:3](=[O:4])[O:5][CH2:6][CH3:7])(=[O:8])[c:14]1[c:13]2[cH:12][cH:11][c:10]([Cl:9])[cH:18][c:17]2[n:16]([CH3:19])[c:15]1[C:20](=[O:21])[O:22][CH2:23][CH3:24]

Participants

Reactant 5

HCID 111,2-Dichloroethane

HCID 312Chloride4×

HCID 20884Ethoxalyl chloride

HCID 114942Titanium cation (4+)

HCID 10561874Ethyl 6-chloro-1-methyl-1H-indole-2-carboxylate

Product 1

HCID 15461899Ethyl 6-chloro-2-(ethoxycarbonyl)-1-methyl-oxo-1h-indole-3-acetate

Sources & evidence

ORD record: ord-eb2e7c12563242a58e92cb46122e519c
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (8/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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