Hydrochloric Acid → N-(2-Cyclopropylethyl)-2-[5-(2-trifluoromethylbenzoyl)-3,4,5,6-tetrahydro-1H-pyrrolo-[3,4-c]pyrrol-2-yl]thiazole-5-carboxamide

HRID 311805

Reaction equation

HRID 311805 reaction equation
[CH3:37][CH2:38][N:39]([CH2:40][CH3:41])[CH2:42][CH3:43].[CH:31]1([CH2:34][CH2:35][NH2:36])[CH2:32][CH2:33]1.[ClH:30].[F:1][C:2]([c:3]1[c:4]([C:5](=[O:6])[N:7]2[CH2:8][C:9]3=[C:10]([CH2:11]2)[CH2:12][N:13]([c:15]2[s:16][c:17]([C:20](=[O:21])[OH:22])[cH:18][n:19]2)[CH2:14]3)[cH:23][cH:24][cH:25][cH:26]1)([F:27])[F:28].[Li:29].[P-:44]([F:45])([F:46])([F:47])([F:48])([F:49])[F:50].[n:51]1([O:52][C:53]([N:54]([CH3:55])[CH3:56])=[N+:57]([CH3:58])[CH3:59])[c:60]2[n:61][cH:62][cH:63][cH:64][c:65]2[n:66][n:67]1>>[F:1][C:2]([c:3]1[c:4]([C:5](=[O:6])[N:7]2[CH2:8][C:9]3=[C:10]([CH2:11]2)[CH2:12][N:13]([c:15]2[s:16][c:17]([C:20](=[O:21])[NH:36][CH2:35][CH2:34][CH:31]4[CH2:32][CH2:33]4)[cH:18][n:19]2)[CH2:14]3)[cH:23][cH:24][cH:25][cH:26]1)([F:27])[F:28]

Participants

8

Reactant 7

HCID 313Hydrochloric AcidHCID 8471TriethylamineHCID 9886HexafluorophosphateHCID 3028194LithiumHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 10240761CyclopropaneethanamineHCID 593609132-[5-(2-Trifluoromethylbenzoyl)-3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl]thiazole-5-carboxylic acid

Product 1

HCID 25105789N-(2-Cyclopropylethyl)-2-[5-(2-trifluoromethylbenzoyl)-3,4,5,6-tetrahydro-1H-pyrrolo-[3,4-c]pyrrol-2-yl]thiazole-5-carboxamide

Sources & evidence

ORD record
ord-b011e2a16c284360998ed8e8ca97d344
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Linked notes

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