Dimethylformamide → 3-(9-Bromo-6-isopropyl-1-oxo-1,2-dihydrobenzo[c]-1,6-naphthyridin-4-yl)prop-2-ynamide

HRID 312672

Reaction equation

HRID 312672 reaction equation
[Br:1][c:2]1[cH:3][c:4]2[c:5]([c:6]([CH:16]([CH3:17])[CH3:18])[n:7][c:8]3[c:9]([I:15])[cH:10][nH:11][c:12](=[O:14])[c:13]23)[cH:19][cH:20]1.[C:21]([C:22]#[CH:23])(=[O:24])[NH2:25].[Cu:26][I:27].[O:105]=[CH:106][N:107]([CH3:108])[CH3:109].[cH:28]1[cH:29][cH:30][c:31]([P:32]([Pd:33]([P:34]([c:35]2[cH:36][cH:37][cH:38][cH:39][cH:40]2)([c:41]2[cH:42][cH:43][cH:44][cH:45][cH:46]2)[c:47]2[cH:48][cH:49][cH:50][cH:51][cH:52]2)([P:53]([c:54]2[cH:55][cH:56][cH:57][cH:58][cH:59]2)([c:60]2[cH:61][cH:62][cH:63][cH:64][cH:65]2)[c:66]2[cH:67][cH:68][cH:69][cH:70][cH:71]2)[P:72]([c:73]2[cH:74][cH:75][cH:76][cH:77][cH:78]2)([c:79]2[cH:80][cH:81][cH:82][cH:83][cH:84]2)[c:85]2[cH:86][cH:87][cH:88][cH:89][cH:90]2)([c:91]2[cH:92][cH:93][cH:94][cH:95][cH:96]2)[c:97]2[cH:98][cH:99][cH:100][cH:101][cH:102]2)[cH:103][cH:104]1>>[Br:1][c:2]1[cH:3][c:4]2[c:5]([c:6]([CH:16]([CH3:17])[CH3:18])[n:7][c:8]3[c:9]([C:23]#[C:22][C:21](=[O:24])[NH2:25])[cH:10][nH:11][c:12](=[O:14])[c:13]23)[cH:19][cH:20]1

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 101445PropynamideHCID 593756199-bromo-4-iodo-6-isopropylbenzo[c]-1,6-naphthyridin-1(2H)-oneHCID 178420554HCID 178420554, compound

Product 1

HCID 593756833-(9-Bromo-6-isopropyl-1-oxo-1,2-dihydrobenzo[c]-1,6-naphthyridin-4-yl)prop-2-ynamide

Sources & evidence

ORD record
ord-9c25482a798b4bb3b8f7301ac969c50b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Linked notes

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