2-(Benzyloxy)benzaldehyde → HCID 22009001, compound

HRID 322021

Reaction equation

HRID 322021 reaction equation
[CH2:1]([O:8][C:9]1[CH:16]=[CH:15][CH:14]=[CH:13][C:10]=1[CH:11]=[O:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:17]([Mg]Br)=[CH2:18]>C1COCC1>[CH2:1]([O:8][C:9]1[CH:16]=[CH:15][CH:14]=[CH:13][C:10]=1[CH:11]([OH:12])[CH:17]=[CH2:18])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 3447842-(Benzyloxy)benzaldehydeHCID 178418507HCID 178418507, compound

Product 1

HCID 22009001HCID 22009001, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2-(benzyloxy)benzaldehyde (5g, 23.6 mmol) was reacted with vinylmagnesium bromide in THF (90 ml) at 0 C. The reaction was quenched with 2 N HCl and the product was extracted in i-PrOAc, dried over Na2SO4 and purified by flash chromatography with EtOAc:toluene 2.5:97.5.

Workup

  1. customThe reaction was quenched with 2 N HCl
  2. extractionthe product was extracted in i-PrOAc
  3. dry with materialdried over Na2SO4
  4. custompurified by flash chromatography with EtOAc:toluene 2.5:97.5

Sources & evidence

ORD record
ord-a4708b1709d247f8a0d9098dd75df039
Source dataset
uspto-grants-2001_04
Patent number
US06211197B1

Linked notes

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