Oxalyl chloride → 2-Methoxy-5-(1H-tetrazol-1-ylmethyl)benzoyl Chloride
Reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:9]([CH2:12][N:13]2[CH:17]=[N:16][N:15]=[N:14]2)=[CH:8][C:4]=1[C:5](O)=[O:6].C(Cl)(=O)C([Cl:21])=O>CN(C)C=O.ClCCl>[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:9]([CH2:12][N:13]2[CH:17]=[N:16][N:15]=[N:14]2)=[CH:8][C:4]=1[C:5]([Cl:21])=[O:6]Participants
5
Procedure
Combine 2-methoxy-5-(1H-tetrazol-1-ylmethyl)benzoic acid (0.35 g, 1.5 mmol) and dichloromethane (25 mL). Add dropwise oxalyl chloride (0.21 mL, 2.35 mmol) followed by dimethylformamide (5 drops). After 4 hours, evaporate in vacuo and dry to give the title compound.
Workup
- customevaporate in vacuo
- customdry
Sources & evidence
- ORD record
- ord-1f9dca26d4cf48daa3c561aa7bef1c4c
- Source dataset
- uspto-grants-2001_04
- Patent number
- US06211199B1
Reaction notes
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