Acetic Anhydride → N-acetoacetyl-L-aspartic anhydride
Reaction equation
[C:1]([NH:7][C@H:8]([C:13]([OH:15])=[O:14])[CH2:9][C:10]([OH:12])=O)(=[O:6])[CH2:2][C:3]([CH3:5])=[O:4].C([O-])(=O)C.[Mg+2].C([O-])(=O)C.C(OC(=O)C)(=O)C>C(OCC)(=O)C>[C:1]([NH:7][C@@H:8]1[C:13](=[O:14])[O:15][C:10](=[O:12])[CH2:9]1)(=[O:6])[CH2:2][C:3]([CH3:5])=[O:4]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 55 °C
Procedure
21.72 parts of N-acetoacetyl-L-aspartic acid, 0.14 parts of magnesium acetate, and 9.5 parts by volume of acetic anhydride were mixed with 200 parts by volume of ethyl acetate and heated at 55±2° C. under argon for 24 hours.
Sources & evidence
- ORD record
- ord-f65be8cf1ac34fd49f886e0589365cbc
- Source dataset
- uspto-grants-1984_04
- Patent number
- US04440677
Reaction notes
Loading…