Acetic Anhydride → N-acetoacetyl-L-aspartic anhydride

HRID 325274

Reaction equation

HRID 325274 reaction equation
[C:1]([NH:7][C@H:8]([C:13]([OH:15])=[O:14])[CH2:9][C:10]([OH:12])=O)(=[O:6])[CH2:2][C:3]([CH3:5])=[O:4].C([O-])(=O)C.[Mg+2].C([O-])(=O)C.C(OC(=O)C)(=O)C>C(OCC)(=O)C>[C:1]([NH:7][C@@H:8]1[C:13](=[O:14])[O:15][C:10](=[O:12])[CH2:9]1)(=[O:6])[CH2:2][C:3]([CH3:5])=[O:4]

Participants

5

Reactant 3

HCID 7918Acetic AnhydrideHCID 8896Magnesium AcetateHCID 13334672N-acetoacetylaspartic acid

Product 1

HCID 13334674N-acetoacetyl-L-aspartic anhydride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
55 °C

Procedure

21.72 parts of N-acetoacetyl-L-aspartic acid, 0.14 parts of magnesium acetate, and 9.5 parts by volume of acetic anhydride were mixed with 200 parts by volume of ethyl acetate and heated at 55±2° C. under argon for 24 hours.

Sources & evidence

ORD record
ord-f65be8cf1ac34fd49f886e0589365cbc
Source dataset
uspto-grants-1984_04
Patent number
US04440677

Linked notes

Loading…