Lithium hydroxide, monohydrate → HCID 58604318, compound
Reaction equation
C[O:2][C:3](=[O:40])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C@@H:12]2[C:16](=[O:17])[N:15]([C@H:18]([C:27](=[O:38])[NH:28][C:29]3[S:30][CH:31]=[C:32]([C:34](=[O:37])[CH2:35][CH3:36])[N:33]=3)[C@H:19]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[CH3:20])[C:14](=[O:39])[NH:13]2)=[CH:8][CH:7]=1.O.[OH-].[Li+]>O1CCCC1>[O:39]=[C:14]1[NH:13][CH:12]([C:9]2[CH:10]=[CH:11][C:6]([O:5][CH2:4][C:3]([OH:40])=[O:2])=[CH:7][CH:8]=2)[C:16](=[O:17])[N:15]1[C@H:18]([C:27](=[O:38])[NH:28][C:29]1[S:30][CH:31]=[C:32]([C:34](=[O:37])[CH2:35][CH3:36])[N:33]=1)[C@H:19]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[CH3:20]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Prepared by hydrolysis of (4-{(R)-2,5-dioxo-1-[(1S,2S)-2-phenyl-1-(4-propionyl-thiazol-2-ylcarbamoyl)-propyl]-imidazolidin-4-yl}-phenoxy)-acetic acid methyl ester (prepared as described in example 21) with lithium hydroxide monohydrate in aqueous tetrahydrofuran. Under the conditions employed for the hydrolysis of the methyl ester racemization occurred at the 4-position of the imidazolidinedione ring.