Cytidine Diphosphate → HCID 86734645, compound

HRID 328551

Reaction equation

HRID 328551 reaction equation
[P:1]([O:9][CH2:10][C@H:11]1[O:15][C@@H:14]([N:16]2[CH:23]=[CH:22][C:20](N)=[N:19][C:17]2=[O:18])[C@H:13]([OH:24])[C@@H:12]1[OH:25])([O:4][P:5]([OH:8])([OH:7])=[O:6])(=[O:3])[OH:2].[OH-:26].[NH4+]>[Rh]>[P:1]([O:9][CH2:10][C@H:11]1[O:15][C@@H:14]([N:16]2[CH:23]=[CH:22][C:20](=[O:26])[NH:19][C:17]2=[O:18])[C@H:13]([OH:24])[C@@H:12]1[OH:25])([O:4][P:5]([OH:8])([OH:7])=[O:6])(=[O:3])[OH:2].[OH:26][CH:20]1[CH2:22][CH2:23][N:16]([C@@H:14]2[O:15][C@H:11]([CH2:10][OH:9])[C@@H:12]([OH:25])[C@H:13]2[OH:24])[C:17](=[O:18])[NH:19]1

Participants

4

Reactant 2

HCID 6132Cytidine DiphosphateHCID 14923Ammonium Hydroxide

Product 1

HCID 86734645HCID 86734645, compound

Reagents, catalysts & solvents 1

HCID 23948RhodiumCatalyst

Procedure

In the manner given in Example 2D, cytidine 5'-diphosphate was hydrogenated in dilute ammonium hydroxide in the presence of a rhodium on alumina catalyst, and the mixture separated with a Craig extractor to give 4-hydroxy-1-β-D-ribofuranosyl-tetrahydro-2(1H)-pyrimidinone uridine 5'-diphosphate and 1-β-D-ribofuranosyl-tetrahydro-2(1H)-pyrimidinone 5'-diphosphate.

Workup

  1. customthe mixture separated with a Craig extractor

Sources & evidence

ORD record
ord-f4a534c9938a426c81e57cbe69dbea59
Source dataset
uspto-grants-1977_04
Patent number
US04017606

Linked notes

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