Dichloromethane → 3-(2-Thienyl)-propanoic acid chloride
Reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH2:7][C:8]([OH:10])=O.C(Cl)[Cl:12]>C(Cl)(=O)C(Cl)=O.CN(C)C=O>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH2:7][C:8]([Cl:12])=[O:10]Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
To a solution of 5.0 g (0.032 mol) of 3-(2-thienyl)propionic acid in 2 ml of methylene chloride and 25 ml of oxalyl chloride was added three drops of N,N-dimethylformamide slowly. Following evolution of the gas the reaction mixture was concentrated under vacuum and 20 ml of hexane was added to the residue. The resulting mixture was filtered and the filtrate was concentrated under vacuum. The resulting compound, 3-(2-thienyl)propionyl chloride, was used directly in the following reaction.
Workup
- concentrationwas concentrated under vacuum and 20 ml of hexane
- additionwas added to the residue
- filtrationThe resulting mixture was filtered
- concentrationthe filtrate was concentrated under vacuum
- customThe resulting compound, 3-(2-thienyl)propionyl chloride, was used directly in the following reaction
Sources & evidence
- ORD record
- ord-2e3424e2761c4ae3b61e15296de10c0d
- Source dataset
- uspto-grants-1990_01
- Patent number
- US04891379
Reaction notes
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