Methylamine → 3-fluoro-N-methyl-2-nitroaniline

HRID 33395

Reaction equation

HRID 33395 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4](F)[C:3]=1[N+:9]([O-:11])=[O:10].[CH3:12][NH2:13]>C1COCC1>[F:1][C:2]1[C:3]([N+:9]([O-:11])=[O:10])=[C:4]([NH:13][CH3:12])[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 879221,3-Difluoro-2-nitrobenzene

Product 1

HCID 544897393-fluoro-N-methyl-2-nitroaniline

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Reaction of 2.0 g (2.6 mmol) 2,6-difluoro-nitrobenzene with a 2 molar solution of methylamine in THF analogously to the process for preparing Intermediate 10a. Red solid. Yield: 1.8 g (86%); mass spectroscopy: [M+H]+=171.

Sources & evidence

ORD record
ord-f358154421284c47883bfa1655f41a75
Source dataset
uspto-grants-2008_09
Patent number
US07429583B2

Linked notes

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