Water → 2-(3-Chloro-phenyl)-2H-tetrazole-5-carboxylic acid
Reaction equation
C([O:3][C:4]([C:6]1[N:7]=[N:8][N:9]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([Cl:17])[CH:12]=2)[N:10]=1)=[O:5])C.O.[Li+].[OH-]>C1COCC1>[Cl:17][C:13]1[CH:12]=[C:11]([N:9]2[N:8]=[N:7][C:6]([C:4]([OH:5])=[O:3])=[N:10]2)[CH:16]=[CH:15][CH:14]=1Participants
5
Procedure
7.00 g (27.7 mmol) 2-(3-chloro-phenyl)-2H-tetrazole-5-carboxylic acid ethyl ester was dissolved in 50 mL THF and 50 mL water and treated with 2.33 g (55.4 mmol) LiOH at RT for 14 h. The reaction mixture was concentrated and acidified with 1 M aqueous hydrochlorid acid. The precipitate was filtered off, washed with water and dried.
Workup
- concentrationThe reaction mixture was concentrated
- filtrationThe precipitate was filtered off
- washwashed with water
- customdried
Sources & evidence
- ORD record
- ord-411eb9e1998e45fa822c29f3798f8244
- Source dataset
- uspto-grants-2014_11
- Patent number
- US08883789B2
Reaction notes
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