Morpholine → (S)-2-fluoro-7-(2-fluoropyridin-3-yl)-3-morpholino-5'H-spiro[chromeno[2,3-b]pyridine-5,4'-oxazol]-2'-amine
Reaction equation
[F:1][C:2]1[N:7]=[C:6]2[O:8][C:9]3[C:14]([C@@:15]4([CH2:19][O:18][C:17]([NH2:20])=[N:16]4)[C:5]2=[CH:4][C:3]=1I)=[CH:13][C:12]([C:21]1[C:22]([F:27])=[N:23][CH:24]=[CH:25][CH:26]=1)=[CH:11][CH:10]=3.[NH:29]1[CH2:34][CH2:33][O:32][CH2:31][CH2:30]1.[Li+].C[Si]([N-][Si](C)(C)C)(C)C>CC(OC1C=CC=C(OC(C)C)C=1C1C(P(C2CCCCC2)C2CCCCC2)=CC=CC=1)C.CC(OC)(C)C.C1C=[C-]C(CCN)=CC=1.Cl[Pd+].C1COCC1>[F:1][C:2]1[N:7]=[C:6]2[O:8][C:9]3[C:14]([C@@:15]4([CH2:19][O:18][C:17]([NH2:20])=[N:16]4)[C:5]2=[CH:4][C:3]=1[N:29]1[CH2:34][CH2:33][O:32][CH2:31][CH2:30]1)=[CH:13][C:12]([C:21]1[C:22]([F:27])=[N:23][CH:24]=[CH:25][CH:26]=1)=[CH:11][CH:10]=3Participants
6
