Piperazine → 1-(4-Methoxypyridin-2-yl)piperazine

HRID 336360

Reaction equation

HRID 336360 reaction equation
Cl[C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][N:3]=1.[NH:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1>CN1CCCC1=O.O>[CH3:9][O:8][C:6]1[CH:5]=[CH:4][N:3]=[C:2]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[CH:7]=1

Participants

5

Reactant 2

HCID 4837PiperazineHCID 19911282-Chloro-4-methoxypyridine

Product 1

HCID 226481321-(4-Methoxypyridin-2-yl)piperazineYield 16.2%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

46 mg 2-chloro-4-methoxy-pyridine and 277 mg piperazine in 2 mL n-methyl-2-pyrrolidinone were stirred 45 min at 140° C. and 30 min at 200° C. under microwave conditions. The reaction was diluted with water and purified by HPLC to give 10 mg desired product.

Workup

  1. custompurified by HPLC

Sources & evidence

ORD record
ord-63fe068426d742b984b82fa0b5cd9a08
Source dataset
uspto-grants-2014_11
Patent number
US08889677B2

Linked notes

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