Hydrochloric Acid → 2-(3-Aminopyridazin-4-yl)cyclohex-2-en-1-one
Reaction equation
O1[C:5]2([CH2:10][CH2:9][CH2:8][CH:7]=[C:6]2[C:11]2[CH:16]=[CH:15][N:14]=[N:13][C:12]=2[NH2:17])[O:4]CC1.Cl>C1COCC1>[NH2:17][C:12]1[N:13]=[N:14][CH:15]=[CH:16][C:11]=1[C:6]1[C:5](=[O:4])[CH2:10][CH2:9][CH2:8][CH:7]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
The reaction and aftertreatment were conducted in the same manner as in Example 67c by using the crude 4-(1,4-dioxaspiro[4.5]dec-6-en-6-yl)pyridazin-3-amine prepared in Example 82c, 2 M hydrochloric acid (0.37 mL) and THF (0.92 mL), to yield the title compound (69 mg, 99%, 2 steps) as a colorless oil.
Workup
- customThe reaction and aftertreatment
Sources & evidence
- ORD record
- ord-634844d5f118469f94b3e0d13a3fb54f
- Source dataset
- uspto-grants-2014_11
- Patent number
- US08889741B2
Reaction notes
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