Pyrazole → HCID 79863038, compound

HRID 337877

Reaction equation

HRID 337877 reaction equation
[NH:1]1[CH:5]=[CH:4][CH:3]=[N:2]1.[CH2:6]([Li])CCC.[CH3:11][C:12]1([CH3:18])[CH2:16][CH2:15][CH2:14][C:13]1=[O:17]>C1COCC1>[CH3:11][C:12]1([CH3:18])[CH2:16][CH2:15][CH2:14][C:13]1([C:3]1[N:2]([CH3:6])[N:1]=[CH:5][CH:4]=1)[OH:17]

Participants

5

Reactant 3

HCID 1048PyrazoleHCID 1382862,2-DimethylcyclopentanoneHCID 178418339Butyllithium

Product 1

HCID 79863038HCID 79863038, compoundYield 7.3%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The reaction and aftertreatment were conducted in the same manner as in Example 8a by using pyrazole (3.70 g, 45.1 mmol), n-butyl lithium (2.69 M solution in hexane; 17 mL, 45.7 mmol), 2,2-dimethylcyclopentanone (5.00 g, 44.6 mmol) and THF (100 mL), to yield the title compound (630 mg, 7.3%) as a colorless solid.

Workup

  1. customThe reaction and aftertreatment

Sources & evidence

ORD record
ord-fd8cd709a1254c549eb6dcc43a7ba25a
Source dataset
uspto-grants-2014_11
Patent number
US08889741B2

Linked notes

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