2,2-Dimethoxypropane → (2,2-Dimethyl-1,3-dioxan-5-yl)methanol

HRID 339632

Reaction equation

HRID 339632 reaction equation
[CH3:1][O:2][C:3]([O:6][CH3:7])([CH3:5])[CH3:4].C[CH:9](CO)[CH2:10][OH:11]>C1COCC1>[CH3:4][C:3]1([CH3:5])[O:6][CH2:7][CH:9]([CH2:10][OH:11])[CH2:1][O:2]1

Participants

4

Reactant 2

HCID 64952,2-DimethoxypropaneHCID 75103Methylpropanediol

Product 1

HCID 3584869(2,2-Dimethyl-1,3-dioxan-5-yl)methanol

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 2,2-dimethoxypropane (5.88 g, 56.5 mmol), 2-methyl-propane-1,3-diol (5.0 g, 47 mmol), and PTSA monohydrate (0.48 g, 2.3 mmol) in THF (100 mL) was stirred O/N at rt. The mixture was concentrated in vacuo to give the title compound as a colorless liquid: yield 6.87 g (99%).

Workup

  1. concentrationThe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-cfb4541aa01a4f7da4634bef9d0cf3d5
Source dataset
uspto-grants-2014_11
Patent number
US08895534B2

Linked notes

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