Hydrochloric Acid → beta-Methyl-alpha-phenyl-1-pyrrolidineethanol hydrochloride

HRID 341947Notes

Reaction equation

HRID 341947 reaction equation
[ClH:1].C1(C)C=CC=CC=1.[CH3:9][CH:10]([N:19]1[CH2:23][CH2:22][CH2:21][CH2:20]1)[CH:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[OH:12]>C(O)(C)C>[ClH:1].[CH3:9][CH:10]([N:19]1[CH2:23][CH2:22][CH2:21][CH2:20]1)[CH:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[OH:12]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 1140TolueneHCID 40795061-Phenyl-2-(pyrrolidin-1-yl)propan-1-ol

Product 1

HCID 53395958beta-Methyl-alpha-phenyl-1-pyrrolidineethanol hydrochloride

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

adding a solution of hydrogen chloride in isopropanol to a toluene solution of [R-(R*,S*)]-β-methyl-α-phenyl-1-pyrrolidineethanol or its enantiomer at about 10° to about 15° C. and maintaining a reaction temperature of about 10° to about 25° C. to form [R-(R*,S*)]-β-methyl-α-phenyl-1-pyrrolidineethanol hydrochloride or its enantiomer;

Workup

  1. temperaturemaintaining a reaction temperature of about 10° to about 25° C.

Sources & evidence

ORD record
ord-291ec677f243435d9c65ff0f059cfb75
Source dataset
uspto-grants-1999_01
Patent number
US05856492

Reaction notes

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