Azobisisobutyronitrile → 2,6-Dichloro-3-nitrobenzyl Bromide

HRID 342611Notes

Reaction equation

HRID 342611 reaction equation
[Br:1]C1(Br)NC(=O)NC1=O.[Cl:10][C:11]1[C:16]([N+:17]([O-:19])=[O:18])=[CH:15][CH:14]=[C:13]([Cl:20])[C:12]=1[CH3:21].CC(N=NC(C#N)(C)C)(C#N)C.CC(=O)OCC>ClC1C=CC=CC=1>[Cl:10][C:11]1[C:16]([N+:17]([O-:19])=[O:18])=[CH:15][CH:14]=[C:13]([Cl:20])[C:12]=1[CH2:21][Br:1]

Participants

6

Reactant 4

HCID 6547AzobisisobutyronitrileHCID 8857Ethyl AcetateHCID 971552,6-Dichloro-3-nitrotolueneHCID 54068228Dibromohydantoin2×

Product 1

HCID 110115352,6-Dichloro-3-nitrobenzyl Bromide

Reagents, catalysts & solvents 1

HCID 7964ChlorobenzeneSolvent

Procedure

A mixture of dibromohydantoin (70 g, 0.24 mol) and AlBN (5 g) was added in portions at 150° C. to 2,6-dichloro-3-nitrotoluene (100 g, 0.48 mol) in chlorobenzene (400 ml). After 1 h, a mixture of dibromohydantoin (35 g, 0.12 mol) and AIBN (2.5 g) was again added. After a further 1.5 h, the mixture was allowed to cool and EA (500 ml) was added. This mixture was washed once each with saturated Na2SO3, Na2CO3 and NaCl solution, dried (MgSO4) and concentrated, the title compound being obtained as an amorphous powder.

Workup

  1. additionwas again added
  2. waitAfter a further 1.5 h
  3. temperatureto cool
  4. washThis mixture was washed once each with saturated Na2SO3, Na2CO3 and NaCl solution
  5. dry with materialdried (MgSO4)
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-b7a568ba3d00424294d137ce07854653
Source dataset
uspto-grants-1999_01
Patent number
US05859025

Reaction notes

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