Benzaldehyde → Ethyl 2-benzylideneaminobutyrate

HRID 342865

Reaction equation

HRID 342865 reaction equation
C(N(CC)CC)C.Cl.[NH2:9][CH:10]([CH2:16][CH3:17])[C:11]([O:13][CH2:14][CH3:15])=[O:12].[CH:18](=O)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>C1(C)C=CC=CC=1>[CH:18](=[N:9][CH:10]([CH2:16][CH3:17])[C:11]([O:13][CH2:14][CH3:15])=[O:12])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

5

Reactant 3

HCID 240BenzaldehydeHCID 8471TriethylamineHCID 12844023Ethyl 2-Aminobutyrate Hydrochloride

Product 1

HCID 10331026Ethyl 2-benzylideneaminobutyrate

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Triethylamine (2 moles) was added to a solution of the product from step (a) (1 mole) in toluene. When addition was complete, benzaldehyde (1 mole) was added. The mixture was azeotroped until no further water was collected, then cooled to room temperature and filtered. The filtrate was evaporated in vacuo ti give the desired product as an oil.

Workup

  1. additionWhen addition
  2. customThe mixture was azeotroped until no further water
  3. customwas collected
  4. filtrationfiltered
  5. customThe filtrate was evaporated in vacuo ti

Sources & evidence

ORD record
ord-410984a921a147c6bb9ce5296f537673
Source dataset
uspto-grants-1999_01
Patent number
US05859240

Linked notes

Loading…