Hydrochloric Acid → Methyl 4-benzyloxybenzimidate hydrochloride
Reaction equation
[CH2:1]([O:8][C:9]1[CH:16]=[CH:15][C:12]([C:13]#[N:14])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:17].C1C[O:21][CH2:20]C1>CO>[ClH:17].[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([C:13](=[NH:14])[O:21][CH3:20])=[CH:15][CH:16]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 560 mg of 4-benzyloxybenzonitrile in 16 ml of THF and 0.2 ml of methanol, cooled to 0° C., was saturated with hydrogen chloride and kept at 4° C. for 16 hours. The precipitate was filtered off, washed with diethyl ether and dried to give 357 mg of methyl 4-benzyloxybenzimidate hydrochloride, m.p. 179°-180° C.
Workup
- filtrationThe precipitate was filtered off
- washwashed with diethyl ether
- customdried
Sources & evidence
- ORD record
- ord-7456a4145aae444eb85ca8084af499b7
- Source dataset
- uspto-grants-1991_10
- Patent number
- US05057614
Reaction notes
Loading…