Diisopropylethylamine → N-(4-Amino-3-thienyl)-N'-(2,4-dichloro-3-thienyl)thiourea

HRID 349432

Reaction equation

HRID 349432 reaction equation
Br.Br.[NH2:3][C:4]1[C:8]([NH2:9])=[CH:7][S:6][CH:5]=1.[Cl:10][C:11]1[S:12][CH:13]=[C:14]([Cl:19])[C:15]=1[N:16]=[C:17]=[S:18].C(N(C(C)C)C(C)C)C>C1COCC1>[NH2:9][C:8]1[C:4]([NH:3][C:17]([NH:16][C:15]2[C:14]([Cl:19])=[CH:13][S:12][C:11]=2[Cl:10])=[S:18])=[CH:5][S:6][CH:7]=1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 21989329Thiophene-3,4-diamine dihydrobromideHCID 597454922,4-Dichloro-3-thienyl isothiocyanate

Product 1

HCID 86037752N-(4-Amino-3-thienyl)-N'-(2,4-dichloro-3-thienyl)thiourea

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

was obtained in a similar manner to the method described in Example 5e by reacting 0.84 g of 3,4-diaminothiophene dihydrobromide with 0.8 g of 2,4-dichloro-3-thienyl isothiocyanate and 0.49 g of N-ethyl-N,N-diisopropylamine in THF. Crystalline product. M.p. 110–115° C.

Workup

  1. customwas obtained in a similar manner to the method

Sources & evidence

ORD record
ord-24dedb0059a44a8e9dcadd4d9f5d393e
Source dataset
uspto-grants-2007_02
Patent number
US07179830B2

Linked notes

Loading…