Hydrochloric Acid → N-tert-Butylglycine

HRID 352206

Reaction equation

HRID 352206 reaction equation
C[O:2][C:3](=[O:10])[CH2:4][NH:5][C:6]([CH3:9])([CH3:8])[CH3:7].[OH-].[Li+].Cl>O1CCOCC1.O>[C:6]([NH:5][CH2:4][C:3]([OH:10])=[O:2])([CH3:9])([CH3:8])[CH3:7]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 2777439Methyl 2-(tert-butylamino)acetate

Product 1

HCID 414246N-tert-Butylglycine

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of tert-Butylamino-acetic acid methyl ester (Maybridge), 122 mg (0.84 mmol) in 10 mL of dioxane was added a solution of 60 mg (2.52 mmol) of lithium hydroxide in 10 mL of water. The reaction mixture was stirred for two hours, acidified to pH=1 with 5 N HCl and concentrated to dryness to yield the crude desired product which was carried on without further purification. MS (IS) 132.1 (M+1).

Workup

  1. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-31f8addea56842a7a11d48ec765271ec
Source dataset
uspto-grants-2004_06
Patent number
US06743794B2

Linked notes

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