Ethanolamine → N-(2-Hydroxyethyl)pyrazine-2-carboxamide
Reaction equation
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[C:7]([O:9]C)=O.[NH2:11][CH2:12][CH2:13][OH:14]>C(OCC)(=O)C>[OH:14][CH2:13][CH2:12][NH:11][C:7]([C:2]1[CH:3]=[N:4][CH:5]=[CH:6][N:1]=1)=[O:9]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 55.2 parts of methyl 2-pyrazinecarboxylate, 48.9 parts of 2-aminoethanol and 360 parts of ethyl acetate was allowed to stand overnight at room temperature. The precipitated product was filtered off, washed with ethyl acetate and dried, yielding 54.5 parts (80%) of N-(2-hydroxyethyl)-2-pyrazinecarboxamide; mp. 125° C. (intermediate 22).
Workup
- filtrationThe precipitated product was filtered off
- washwashed with ethyl acetate
- customdried
Sources & evidence
- ORD record
- ord-5c89f624e3c24f21936bf0d2ca764d41
- Source dataset
- uspto-grants-1988_08
- Patent number
- US04766125
Reaction notes
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