Acetyl chloride → 1-(4-(Methylthio)phenyl)ethan-1-one

HRID 357639

Reaction equation

BrC(Br)=O.[C:5]1([S:11][CH3:12])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[C:13](Cl)(=[O:15])[CH3:14]>>[CH3:14][C:13]([C:8]1[CH:9]=[CH:10][C:5]([S:11][CH3:12])=[CH:6][CH:7]=1)=[O:15]

Participants

Reactant 3

HCID 6367Acetyl chloride

HCID 7520Thioanisole

HCID 79057Carbonyl bromide

Product 1

HCID 745011-(4-(Methylthio)phenyl)ethan-1-one

Procedure

The synthesis of bromoketone 2 begins with the Friedel-Crafts reaction between thioanisole and acetyl chloride, to give 4-(methylthio)acetophenone 3 herein referred to as ketosulfide 3).

Sources & evidence

ORD record: ord-e4494d6d1d164f64b3a7b30b7bdc8aa6
Source dataset: uspto-grants-1998_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05840924

Linked notes

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