1H-1,2,4-Triazole → Quinazoline
Reaction equation
O=P(Cl)(Cl)Cl.O[C:7]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]=[CH:9][N:8]=1.N1C=NC=N1>N1C=CC=CC=1>[N:10]1[C:11]2[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:7]=[N:8][CH:9]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
Intermediates of formula (3) wherein L is 1,2,4-triazol-1-yl, can be prepared, for example, by adding POCl3 dropwise to a mixture of a 4-hydroxyquinazoline (1 equiv.) of formula (9) and 1,2,4-triazole (3 equiv.) in pyridine at room temperature.
Sources & evidence
- ORD record
- ord-d59970963f2240559b489333de83ca79
- Source dataset
- uspto-grants-1995_05
- Patent number
- US05411963
Reaction notes
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