2,6-Dichloropyridine → 2-Chloro-6-hydrazinopyridine

HRID 358582Notes

Reaction equation

HRID 358582 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4](Cl)[N:3]=1.O.[NH2:10][NH2:11]>CO>[NH:10]([C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[N:3]=1)[NH2:11]

Participants

4

Reactant 2

HCID 169892,6-DichloropyridineHCID 24654Hydrazine hydrate (1:1)

Product 1

HCID 3200042-Chloro-6-hydrazinopyridine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

2 g of 2,6-dichloropyridine were dissolved in 60 ml of methanol and mixed with 10 ml of 80% hydrazine hydrate. The solution was firstly stirred for 3 days at room temperature and then refluxed for 10 days. Rotation in took place, the residue was taken up with methanol, followed by rotation in again and finally recrystallization from methanol/water. 0.25 g of 2-hydrazino-6-chloropyridine was obtained.

Workup

  1. temperaturerefluxed for 10 days
  2. customfinally recrystallization from methanol/water

Sources & evidence

ORD record
ord-c51d8063c54a4e6b814342ca1f318ddc
Source dataset
uspto-grants-1991_03
Patent number
US04997835

Reaction notes

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