Hydrochloric Acid → Isopropyl L-methionate hydrochloride
Reaction equation
[ClH:1].[CH:2]([O:5][C:6](=[O:20])[C@H:7]([CH2:16][CH2:17][S:18][CH3:19])[NH:8]C(OC(C)(C)C)=O)([CH3:4])[CH3:3]>CCOC(C)=O>[ClH:1].[CH:2]([O:5][C:6](=[O:20])[C@H:7]([CH2:16][CH2:17][S:18][CH3:19])[NH2:8])([CH3:4])[CH3:3]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- -20 °C
Procedure
HCl gas was bubbled into a solution of N-(t-Butoxycarbonyl methionine isopropyl ester (20.5 g, 0.07 mol) in EtOAc (200 mL) with stirring and cooling to -20° C. for 10 min. The flask was stoppered and stirred at -20° C. for 1 h, argon was bubbled into the solution to remove excess HCl, then the solution was concentrated to dryness to give a white solid which was used without further purification.
Workup
- stirringstirred at -20° C. for 1 h
- customargon was bubbled into the solution
- customto remove excess HCl
- concentrationthe solution was concentrated to dryness
- customto give a white solid which
- customwas used without further purification
Sources & evidence
- ORD record
- ord-8eb6aac7aa984f6d94b01c595e9dc660
- Source dataset
- uspto-grants-1999_02
- Patent number
- US05872135
Reaction notes
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