Phosphorus tribromide → 1-(Bromomethyl)-3-chlorobenzene
Reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH2:5]O.P(Br)(Br)[Br:11]>O1CCCC1>[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH2:5][Br:11]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 0 °C
Procedure
A solution of 260 ul of 3-chlorobenzyl alcohol dissolved in 2.5 ml of dry tetrahydrofuran is cooled to 0° C. and 120 ul of PBr3 added. The reaction is stirred for 3 hours and extracted with ether. The organic layer is washed with saturated sodium bicarbonate and evaporated to give the desired product.
Workup
- extractionextracted with ether
- washThe organic layer is washed with saturated sodium bicarbonate
- customevaporated
Sources & evidence
- ORD record
- ord-2e356bec6541419499a7e4e5503f2522
- Source dataset
- uspto-grants-1995_05
- Patent number
- US05414001
Reaction notes
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