Phosphorus tribromide → 3-Methoxybenzyl bromide
Reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH2:6]O.P(Br)(Br)[Br:12]>O1CCCC1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH2:6][Br:12]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 270 ul of 3-methoxybenzyl alcohol in 2.5 ml of dry tetrahydrofuran is cooled to 0° C. and 120 ul PBr3 added, followed by stirring for three hours. The reaction mixture is extracted with ether and the organic layer washed with saturated sodium bicarbonate and evaporated to give the desired product.
Workup
- extractionThe reaction mixture is extracted with ether
- washthe organic layer washed with saturated sodium bicarbonate
- customevaporated
Sources & evidence
- ORD record
- ord-d0021b55fed847d8be332381521d5721
- Source dataset
- uspto-grants-1995_05
- Patent number
- US05414001
Reaction notes
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