Potassium Carbonate → 1-(2-Hydrazinylethyl)pyrrolidine

HRID 364182

Reaction equation

HRID 364182 reaction equation
O.[NH2:2][NH2:3].Cl.Cl[CH2:6][CH2:7][N:8]1[CH2:12][CH2:11][CH2:10][CH2:9]1.C(=O)([O-])[O-].[K+].[K+].[OH-].[Na+]>O>[NH:2]([CH2:6][CH2:7][N:8]1[CH2:12][CH2:11][CH2:10][CH2:9]1)[NH2:3]

Participants

6

Reactant 4

HCID 11430Potassium CarbonateHCID 14798Sodium HydroxideHCID 24654Hydrazine hydrate (1:1)HCID 816681-(2-Chloroethyl)pyrrolidine hydrochloride

Product 1

HCID 30315561-(2-Hydrazinylethyl)pyrrolidine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 200 g of 85% hydrazine hydrate, 200 ml of water, 170 g of N-chloroethylpyrrolidine hydrochloride, and 70 g of potassium carbonate was boiled under reflux for seven hours. Sodium hydroxide (390 g) was added and the mixture was extracted with ether. The ethereal extract, dried and distilled, yielded the title compound, bp 107°-111° C. (18.5 mm).

Workup

  1. temperatureunder reflux for seven hours
  2. extractionthe mixture was extracted with ether
  3. extractionThe ethereal extract
  4. customdried
  5. distillationdistilled

Sources & evidence

ORD record
ord-16204511989e437e8028f0fb62d2c3b9
Source dataset
uspto-grants-1986_08
Patent number
US04604390

Linked notes

Loading…