Ammonium Hydroxide → Benzenesulfonamide, 2-(4-isoxazolyl)-
Reaction equation
[O:1]1[CH:5]=[C:4]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[S:12](Cl)(=[O:14])=[O:13])[CH:3]=[N:2]1.[OH-].[NH4+:17]>O1CCCC1>[O:1]1[CH:5]=[C:4]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[S:12]([NH2:17])(=[O:14])=[O:13])[CH:3]=[N:2]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
By the procedure of Example 5, 15 g of 2-(isoxazol-4-yl)benzenesulfonyl chloride prepared in Example 12 was reacted with 30 ml of concentrated ammonium hydroxide in 150 ml of tetrahydrofuran to give, after recrystallization from 2-propanol, 11 g of the title compound; m.p. 165°-167° C.
Workup
- customto give
- customafter recrystallization from 2-propanol, 11 g of the title compound
Sources & evidence
- ORD record
- ord-5d6cba0442b74399b6e9c464ec03e485
- Source dataset
- uspto-grants-1986_08
- Patent number
- US04606755
Reaction notes
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