Citric Acid → DL-Malate

HRID 36554

Reaction equation

HRID 36554 reaction equation
[C:1]([OH:13])(=[O:12])[CH2:2][C:3]([CH2:8][C:9]([OH:11])=[O:10])([C:5]([OH:7])=[O:6])[OH:4].C(O)[C@H]1OC(=O)[C@H](O)[C@@H](O)[C@@H]1O.[C:26]([OH:34])(=[O:33])[CH:27]([CH2:29][C:30]([OH:32])=[O:31])[OH:28].C(=O)(O)[O-].[Na+:39]>>[C:1]([O-:13])(=[O:12])[CH2:2][C:3]([CH2:8][C:9]([OH:11])=[O:10])([C:5]([OH:7])=[O:6])[OH:4].[Na+:39].[C:26]([O-:34])(=[O:33])[CH:27]([CH2:29][C:30]([O-:32])=[O:31])[OH:28]

Participants

6

Reactant 4

HCID 311Citric AcidHCID 525Malic AcidHCID 7027delta-GluconolactoneHCID 516892Sodium Bicarbonate

Product 2

HCID 160434DL-MalateHCID 23666341Monosodium Citrate

Procedure

Process: Apply crystallized citric acid, then heat to 60° C. and wet with 36 ml of gluconic acid delta-lactone solution (10 parts of gluconic acid delta-lactone to 5 parts of water); apply malic acid, then allow sodium bicarbonate I to react to give monosodium citrate and malate and then allow sodium bicarbonate II, calcium carbonate and potassium bicarbonate to undergo partial reaction (partial conversion to the citrate). Then cover the surface with citric acid powder. Finally allow sodium carbonate to undergo partial reaction, and dry in vacuo. This effervescent base is mixed with 500 parts of aspirin and with corresponding additives.

Workup

  1. customto react

Sources & evidence

ORD record
ord-b21f295b723640c999e6fa015768ecb3
Source dataset
uspto-grants-1995_05
Patent number
US05415870

Linked notes

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