1-Hydroxybenzotriazole → piperidine N,N-dimethylformamide

HRID 365676

Reaction equation

HRID 365676 reaction equation

C[CH2:2][N:3]([CH:7](C)C)[CH:4](C)C.[CH:10]1[CH:11]=[CH:12]C2N([OH:19])N=[N:16][C:14]=2[CH:15]=1>CN1CCCC1=O>[NH:16]1[CH2:12][CH2:11][CH2:10][CH2:15][CH2:14]1.[CH3:7][N:3]([CH:2]=[O:19])[CH3:4]

Participants

4

Reactant 2

HCID 757711-Hydroxybenzotriazole

HCID 81531Diisopropylethylamine

Product 1

HCID 23501187piperidine N,N-dimethylformamide

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

125 ml of 2.6 g Bop/1-methyl-2-pyrrolidone +1.7 ml of DIEA +0.8 g of HOBt (15 hours, two times)

Sources & evidence

ORD record: ord-8aaecd5f6ac64646b1fa047fffa1fc7c
Source dataset: uspto-grants-2000_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06127519

Linked notes

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