Pyridine-2-carbonitrile → HCID 18460061, compound

HRID 367790

Reaction equation

[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][N:4]=1)#[N:2].[NH2:9][C:10]1[S:11][C:12]([CH3:21])=[C:13]([CH3:20])[C:14]=1[C:15](OCC)=O.O=P(Cl)(Cl)[Cl:24]>>[Cl:24][C:15]1[C:14]2[C:13]([CH3:20])=[C:12]([CH3:21])[S:11][C:10]=2[N:9]=[C:1]([C:3]2[CH:8]=[CH:7][CH:6]=[CH:5][N:4]=2)[N:2]=1

Participants

Reactant 3

HCID 7522Pyridine-2-carbonitrile

HCID 24813Phosphorus oxychloride

HCID 78536Ethyl 2-amino-4,5-dimethyl3-thenoate

Product 1

HCID 18460061HCID 18460061, compound

Procedure

With the procedure of Example 477, the reaction of 2-cyanopyridine and 2-amino-4,5-dimethyl-3-ethoxycarbonyl-thiophene, and the subsequent reaction with POCl3 yields 4-chloro-2-(pyridin-2-yl)-5,6-dimethyl-thieno-[2,3-d]-pyrimidine

Sources & evidence

ORD record: ord-15a60684f284494ca7cc9908012a4cbf
Source dataset: uspto-grants-2000_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06133271

Linked notes

Loading…