Hydrogen Peroxide → 4,4,5,8-Tetramethylthiochroman-6-carboxylic acid-1,1-dioxide

HRID 368934

Reaction equation

[CH3:1][C:2]1([CH3:17])[C:11]2[C:6](=[C:7]([CH3:16])[CH:8]=[C:9]([C:13]([OH:15])=[O:14])[C:10]=2[CH3:12])S[CH2:4][CH2:3]1.OO.[S:20]([O-:23])(O)=[O:21].[Na+]>C(O)(=O)C>[CH3:17][C:2]1([CH3:1])[C:11]2[C:6](=[C:7]([CH3:16])[CH:8]=[C:9]([C:13]([OH:15])=[O:14])[C:10]=2[CH3:12])[S:20](=[O:23])(=[O:21])[CH2:4][CH2:3]1

Participants

Conditions

Temperature: 80 °C

Procedure

4 ml of acetic acid was added to 5 9 (0.02 mol) of 4,4,5,8-tetramethylthiochroman-6-carboxylic acid, further, 6.9 g (0.06 mol) of a 30% hydrogen peroxide aqueous solution was added, and the mixture was heated at 80° C. for 2 hours. 50 ml of a 2% sodium hydrogensulfite aqueous solution was added to the reaction mixture, and a precipitated solid was recovered by filtration to give 5.1 g (yield 90%) of 4,4,5,8-tetramethylthiochroman-6-carboxylic acid-1,1-dioxide.

Workup

filtrationa precipitated solid was recovered by filtration

Sources & evidence

ORD record: ord-bf03c74ac3aa4bf28e9e7c033e4e2bce
Source dataset: uspto-grants-2000_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06136755

Linked notes

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