HomeMCPWorkbenchSkills
HomeWorkbenchNotificationsMe
llms.txt · MCP GuidePrivacy Policy · Terms of Service · Supportv1.8.0
  1. Home
  2. /Reaction

Acetone → 2-Amino-9-(2-deoxy-2-fluoro-beta-D-ribofuranosyl)-9H-purine bis hydrochloride

HRID 37086
Notes
Print preview

Reaction equation

HRID 37086 reaction equation
[NH2:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[C@@H:11]2[O:16][C@H:15]([CH2:17][OH:18])[C@@H:13]([OH:14])[C@H:12]2[F:19])=[CH:4][N:3]=1.C(O)(C)C.[ClH:24].CC(C)=O>CO>[ClH:24].[ClH:24].[NH2:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[C@@H:11]2[O:16][C@H:15]([CH2:17][OH:18])[C@@H:13]([OH:14])[C@H:12]2[F:19])=[CH:4][N:3]=1
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 4

HCID 180AcetoneHCID 313Hydrochloric AcidHCID 3776IsopropanolHCID 10355712(2R,3R,4R,5R)-5-(2-Amino-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol

Product 1

HCID 867486882-Amino-9-(2-deoxy-2-fluoro-beta-D-ribofuranosyl)-9H-purine bis hydrochloride

Reagents, catalysts & solvents 1

HCID 887
Methanol
Solvent

Procedure

To a solution of 2-amino-9-(2-deoxy-2-fluoro-β-D-ribofuranosyl)-9H-purine (300 mg 1.11 mmol) in MeOH (20 ml) was added isopropanol (2.5 ml) previously saturated with hydrochloride (HCL) gas. Acetone (15 ml) was added and the solution evaporated to almost dryness under vacuum at room temperature. Trituration with ethyl acetate (15 ml) produced a white solid which was filtered and washed with ether.

Workup

  1. customthe solution evaporated to almost dryness under vacuum at room temperature
  2. customTrituration with ethyl acetate (15 ml) produced a white solid which
  3. filtrationwas filtered
  4. washwashed with ether

Sources & evidence

ORD record
ord-28097341039e4cbe8dc7d52b6100e3d6
Source dataset
uspto-grants-1995_05
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US05420115

Reaction notes

Loading…

On this pageParticipantsProcedureWorkupSources & evidenceReaction notes