Sodium 2-ethylhexanoate → Disodium 2-sulfido-4-pyridinecarboxylate

HRID 371239

Reaction equation

HRID 371239 reaction equation
[SH:1][C:2]1[CH:7]=[C:6]([C:8]([OH:10])=[O:9])[CH:5]=[CH:4][N:3]=1.C(C(CCCC)C([O-])=O)C.[Na+:21]>O1CCCC1.CO.C(O)(C)C>[S-:1][C:2]1[CH:7]=[C:6]([C:8]([O-:10])=[O:9])[CH:5]=[CH:4][N:3]=1.[Na+:21].[Na+:21]

Participants

6

Reactant 2

HCID 23672331Sodium 2-ethylhexanoateHCID 178524564HCID 178524564, compound

Product 1

HCID 20274573Disodium 2-sulfido-4-pyridinecarboxylate

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 3776IsopropanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a suspension of 2-mercapto-4-pyridinecarboxylic acid (7.65 g) in a mixture of tetrahydrofuran (60 ml) and methanol (60 ml) was added a solution of sodium 2-ethylhexanoate in isopropyl alcohol (27.5%) and the mixture was stirred for 2 days at room temperature. The reaction mixture was evaporated and the residue was washed with a mixture of acetone and ethanol. The crystals were collected by filtration dried over phosphorus pentoxide to give disodium 2-sulfido-4-pyridinecarboxylate (8.5 g).

Workup

  1. customThe reaction mixture was evaporated
  2. washthe residue was washed with a mixture of acetone and ethanol
  3. filtrationThe crystals were collected by filtration
  4. dry with materialdried over phosphorus pentoxide

Sources & evidence

ORD record
ord-20d7e9d4787c44fcb4be7c1aaff8b27d
Source dataset
uspto-grants-1985_07
Patent number
US04529802

Linked notes

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