Hydrochloric Acid → 4-[(2-Methylimidazo(1,2-a)pyridin 3-yl)methyl]benzonitrile hydrochloride
Reaction equation
[CH3:1][C:2]1[N:3]=[C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][N:5]2[C:10]=1[CH2:11][C:12]1[CH:19]=[CH:18][C:15]([C:16]#[N:17])=[CH:14][CH:13]=1.C(OCC)(=O)C.[ClH:26]>C(O)C>[ClH:26].[CH3:1][C:2]1[N:3]=[C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][N:5]2[C:10]=1[CH2:11][C:12]1[CH:13]=[CH:14][C:15]([C:16]#[N:17])=[CH:18][CH:19]=1Participants
5
Procedure
A mixture of 5 g of the product of Stage C, 80 ml of ethyl acetate and 3.5 ml of 6.6N hydrochloric acid in ethanol was ice-cooled, separated, washed with ethyl acetate and dried under reduced pressure at 80° C. to obtain 5 g of the expected product melting at 230° C.
Workup
- temperaturecooled
- customseparated
- washwashed with ethyl acetate
- customdried under reduced pressure at 80° C.
Sources & evidence
- ORD record
- ord-b3cf45a581c645b7b3b59ebc105efcb5
- Source dataset
- uspto-grants-1995_05
- Patent number
- US05420138
Reaction notes
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