Ethyl Acrylate → Ethyl 3-[4-(4-chlorobenzyl)-piperazin-1-yl]-propionate

HRID 372837

Reaction equation

HRID 372837 reaction equation
[C:1]([O:5][CH2:6][CH3:7])(=[O:4])[CH:2]=[CH2:3].[Cl:8][C:9]1[CH:21]=[CH:20][C:12]([CH2:13][N:14]2[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)=[CH:11][CH:10]=1>C(O)C>[Cl:8][C:9]1[CH:21]=[CH:20][C:12]([CH2:13][N:14]2[CH2:19][CH2:18][N:17]([CH2:3][CH2:2][C:1]([O:5][CH2:6][CH3:7])=[O:4])[CH2:16][CH2:15]2)=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 8821Ethyl AcrylateHCID 1348264-Chlorobenzylpiperazine

Product 1

HCID 20326894Ethyl 3-[4-(4-chlorobenzyl)-piperazin-1-yl]-propionateYield 92.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Analogously to Example 1a, 30 g (0.3 mol) ethyl acrylate and 63.2 g 1-(4-chlorobenzyl)-piperazine are reacted in 200 ml ethanol to give 86.5 g (92.8% of theory) ethyl 3-[4-(4-chlorobenzyl)-piperazin-1-yl]-propionate; b.p. 150° - 160° C./0.1 mm Hg.

Sources & evidence

ORD record
ord-323212d42a5a467087745b51dab23c98
Source dataset
uspto-grants-1978_05
Patent number
US04092416

Linked notes

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