Gamma-Butyrolactone → 8-Bromo-2,3,4,5-tetrahydrobenzo[b]oxepine

HRID 373548

Reaction equation

HRID 373548 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.[C:9]1(=O)O[CH2:12][CH2:11][CH2:10]1>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]2[CH2:9][CH2:10][CH2:11][CH2:12][O:8][C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 7302Gamma-ButyrolactoneHCID 115633-Bromophenol

Product 1

HCID 199355348-Bromo-2,3,4,5-tetrahydrobenzo[b]oxepine

Procedure

m-Bromophenol was reacted with γ-butyrolactone in analogy to Example 17, paragraphs B, C and D, to give 8-bromo-2,3,4,5-tetrahydro-1-benzoxepine.

Sources & evidence

ORD record
ord-53b5d9b21b7644e081b762608c11413b
Source dataset
uspto-grants-1992_11
Patent number
US05164387

Linked notes

Loading…