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Acetate → 6-acetylamino-1-(3-methylbenzyl)-4-methylhexahydro-1H-1,4-diazepine

HRID 374111
Notes
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Reaction equation

HRID 374111 reaction equation
C([O-])(=O)C.[C:5]([NH:8][CH:9]1[CH2:15][N:14]([CH3:16])[CH2:13][CH2:12][NH:11][CH2:10]1)(=[O:7])[CH3:6].[CH3:17][C:18]1[CH:19]=[C:20]([CH:23]=[CH:24][CH:25]=1)[CH2:21]Cl.C(=O)([O-])[O-].[K+].[K+].[I-].[Na+]>C(C(C)=O)C>[C:5]([NH:8][CH:9]1[CH2:10][N:11]([CH2:17][C:18]2[CH:25]=[CH:24][CH:23]=[C:20]([CH3:21])[CH:19]=2)[CH2:12][CH2:13][N:14]([CH3:16])[CH2:15]1)(=[O:7])[CH3:6]
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

7

Reactant 5

HCID 175AcetateHCID 5238Sodium IodideHCID 11430Potassium CarbonateHCID 12102m-Xylyl chlorideHCID 152061556-acetylamino-1-methylhexahydro-1H-1,4-diazepine

Product 1

HCID 149989916-acetylamino-1-(3-methylbenzyl)-4-methylhexahydro-1H-1,4-diazepine

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

A mixture of acetate of 6-acetylamino-1-methylhexahydro-1H-1,4-diazepine (3.0 g), 3-methylbenzyl chloride (3.5 g), potassium carbonate (17 g), sodium iodide (0.1 g) and methyl ethyl ketone (200 ml) is refluxed with stirring for 16 hours. The reaction mixture is filtered, and the filtrate is concentrated under reduced pressure. The residue is chromatographed on silica gel with elution of chloroform-methanol (20:1). Fractions containing the title compound are pooled and evaporated under reduced pressure to give the title compound as an oil.

Workup

  1. temperatureis refluxed
  2. filtrationThe reaction mixture is filtered
  3. concentrationthe filtrate is concentrated under reduced pressure
  4. customThe residue is chromatographed on silica gel with elution of chloroform-methanol (20:1)
  5. additionFractions containing the title compound
  6. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-ad9e5766f2a34d56ae5126485c82708d
Source dataset
uspto-grants-1992_11
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US05166341

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes