Triethylamine → HCID 178418557, compound

HRID 3795

Reaction equation

HRID 3795 reaction equation
[CH:1]([N:4]=[C:5]=[O:6])([CH3:3])[CH3:2].[ClH:7].Cl.[Cl:9][C:10]1[CH:26]=[CH:25][C:13]([CH2:14][N:15]2[CH2:20][CH2:19][N:18]([CH2:21][CH2:22][CH2:23][SH:24])[CH2:17][CH2:16]2)=[CH:12][CH:11]=1.C(N(CC)CC)C>C(Cl)Cl>[ClH:9].[ClH:7].[CH:1]([NH:4][C:5](=[SH:24][CH2:23][CH2:22][CH2:21][N:18]1[CH2:19][CH2:20][N:15]([CH2:14][C:13]2[CH:12]=[CH:11][C:10]([Cl:9])=[CH:26][CH:25]=2)[CH2:16][CH2:17]1)[OH:6])([CH3:3])[CH3:2]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 61277Isopropyl isocyanateHCID 137311183-[4-(4-Chlorobenzyl)piperazin-1-yl]propanethiol dihydrochloride

Product 1

HCID 178418557HCID 178418557, compoundYield 56.3%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The procedure described in Example 2 was followed, using 0.5 g of isopropyl isocyanate, 2.0 g of 3-[4-(4-chlorobenzyl)piperazin-1-yl]propanethiol dihydrochloride, 0.7 g of triethylamine and 50 ml of methylene chloride, to give 0.7 g (28% of theory) of N-isopropyl-S-{3-[4-(4-chlorobenzyl)piperazin-1-yl]propyl}thiocarbamate dihydrochloride as a white crystalline solid, M.p. 247°-250° C.

Sources & evidence

ORD record
ord-2a06c362448a46898ee87d972b4b0e1c
Source dataset
uspto-grants-1988_02
Patent number
US04722926

Linked notes

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