Dimethylformamide dimethyl acetal → (E)-ethyl 2-((dimethylamino)methylene)-3-oxopentanoate
Reaction equation
[O:1]=[C:2]([CH2:9][CH3:10])[CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5].CO[CH:13](OC)[N:14]([CH3:16])[CH3:15]>CN(C=O)C>[CH3:13][N:14](/[CH:16]=[C:3](\[C:2](=[O:1])[CH2:9][CH3:10])/[C:4]([O:6][CH2:7][CH3:8])=[O:5])[CH3:15]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
According to Scheme 9 Step 1: A solution of ethyl 3-oxopentanoate (13.9 mmol, 2.00 g) and of 1,1-dimethoxy-N,N-dimethylmethanamine (13.9 mmole, 1.84 mL) in DMF (10 mL) was microwaved for 30 min at 120° C. After evaporation of the solvent, 2.76 g (13.9 mmol) of (E)-ethyl 2-((dimethylamino)methylene)-3-oxopentanoate were obtained and used without further purification.
Workup
- customAfter evaporation of the solvent
Sources & evidence
- ORD record
- ord-36ed30f54e374bdc94cf8a2fd6430b5a
- Source dataset
- uspto-grants-2013_09
- Patent number
- US08524718B2
Reaction notes
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