Hydrochloric Acid → (E)-4-Methyl-1-(2-pyridyl)-2-styryl-1H-benzimidazole hydrochloride

HRID 382549

Reaction equation

HRID 382549 reaction equation
[CH3:1][C:2]1[C:10]2[N:9]=[C:8](/[CH:11]=[CH:12]/[C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[NH:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.F[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][N:21]=1.N1C=CC=CC=1N1C2C=CC=CC=2N=C1/C=C/C1C=CC=CC=1.[ClH:49]>CO>[ClH:49].[CH3:1][C:2]1[C:10]2[N:9]=[C:8](/[CH:11]=[CH:12]/[C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[N:7]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][N:21]=3)[C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 97462-FluoropyridineHCID 9796241(E)-1-(2-pyridyl)-2-styryl-1H-benzimidazoleHCID 22736633(E)-4-methyl-2-styryl-1H-benzimidazole

Product 1

HCID 22736702(E)-4-Methyl-1-(2-pyridyl)-2-styryl-1H-benzimidazole hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Free base of the titled compound was prepared from (E)-4-methyl-2-styryl-1H-benzimidazole and 2-fluoropyridine according to the preparation of (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole (Example 1, method B). The free base was treated with a 10% methanol solution of hydrogen chloride and concentrated to dryness. The residue was recrystallized from 2-propanol/isopropyl ether to give the titled compound.

Workup

  1. concentrationconcentrated to dryness
  2. customThe residue was recrystallized from 2-propanol/isopropyl ether

Sources & evidence

ORD record
ord-11771a375be945f090140bdf8e6bea06
Source dataset
uspto-grants-2001_10
Patent number
US06310079B1

Linked notes

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