Hydrochloric Acid → 2-Carbamoyl-5-phenyl-1,3-thiazole-4-carboxylic acid
Reaction equation
[C:1]([C:3]1[S:4][C:5]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[C:6]([C:8]([O:10]CC)=[O:9])[N:7]=1)#[N:2].[OH-:19].[K+].Cl>C1COCC1>[C:1]([C:3]1[S:4][C:5]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[C:6]([C:8]([OH:10])=[O:9])[N:7]=1)(=[O:19])[NH2:2]Participants
5
Procedure
To a solution of ethyl 2-cyano-5-phenyl-1,3-thiazole-4-carboxylate in THF was added a 1 M aqueous KOH solution, followed by stirring at room temperature for 12 hours. To the reaction mixture was added 1 M hydrochloric acid, and the solid precipitated was collected by filtration to obtain 2-carbamoyl-5-phenyl-1,3-thiazole-4-carboxylic acid as a pale yellow solid.
Workup
- customthe solid precipitated
- filtrationwas collected by filtration
Sources & evidence
- ORD record
- ord-7ad16357e7ad449fb3a65a376802ff60
- Source dataset
- uspto-grants-2013_02
- Patent number
- US08367696B2
Reaction notes
Loading…