2-Methyl-2-butanol → 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-({6-[(2-hydroxy-2-methylpropoxy)methyl]pyridin-2-yl}amino)thiophene-3-carboxamide

Reaction equation

C(O)(CC)(C)C.[NH2:7][C:8]1[S:9][C:10]([C:16]2[C:21]([F:22])=[CH:20][C:19]([C:23]([OH:26])([CH3:25])[CH3:24])=[CH:18][C:17]=2[F:27])=[CH:11][C:12]=1[C:13]([NH2:15])=[O:14].C1(P(C2CCCCC2)C2C=CC=CC=2C2C(C(C)C)=CC(C(C)C)=CC=2C(C)C)CCCCC1.C(=O)([O-])[O-].[K+].[K+].Br[C:69]1[N:74]=[C:73]([CH2:75][O:76][CH2:77][C:78]([CH3:81])([OH:80])[CH3:79])[CH:72]=[CH:71][CH:70]=1>CO.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd]>[F:22][C:21]1[CH:20]=[C:19]([C:23]([OH:26])([CH3:24])[CH3:25])[CH:18]=[C:17]([F:27])[C:16]=1[C:10]1[S:9][C:8]([NH:7][C:69]2[CH:70]=[CH:71][CH:72]=[C:73]([CH2:75][O:76][CH2:77][C:78]([OH:80])([CH3:79])[CH3:81])[N:74]=2)=[C:12]([C:13]([NH2:15])=[O:14])[CH:11]=1