Hydrogen Peroxide → 3-Fluoroisonicotinic acid 1-oxide

HRID 39508

Reaction equation

HRID 39508 reaction equation
[F:1][C:2]1[CH:10]=[N:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[OH:11]O>C(O)(=O)C>[F:1][C:2]1[CH:10]=[N+:9]([O-:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 3453613-Fluoropyridine-4-carboxylic acid

Product 1

HCID 576496373-Fluoroisonicotinic acid 1-oxide

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
75 °C

Procedure

To a solution of 3-fluoroisonicotinic acid (5.0 g, 35.33 mmol) in acetic acid (25 ml) was added hydrogen peroxide (6 ml). The reaction mixture was stirred at 70-80° C. overnight. The solvent was removed to obtain 5.5 g of 3-fluoroisonicotinic acid 1-oxide in quantitative yield.

Workup

  1. customThe solvent was removed

Sources & evidence

ORD record
ord-eefb4f777a6c4d60abf2477d1e1f9e78
Source dataset
uspto-grants-2013_09
Patent number
US08524911B2

Linked notes

Loading…